ETHNIC POLYMORPHISM OF P-450 CITOCHROMIUM
ISOENZYMES IN CHILDREN RESIDING IN ASTRAKHAN REGION

Kantemirova Bela Ismailovna, Candidate of medical sciences, associate professor, sub-department of pediatrics, Astrakhan State Medical Academy(Astrakhan, 121 Bakinskaya str.), belakantemirova@rambler.ru
Griganov Vladimir Ivanovich, Doctor of medical sciences, professor, head of sub-department of pediatrics, Astrakhan State Medical Academy (Astrakhan, 121 Bakinskaya str.), agma@astranet.ru

616.36:577.15

For the first time in the Astrakhan region the authors have studied the genetic polymorphism CYP1A2 on the polymorphic marker С734A, CYP2C19 on the polymorphic marker G681A, CYP2D6 on the polymorphic marker G1934A, in groups of children of five various nationalities living on the territory of Astrakhan region. The researchers have revealed ethnic features in distribution of frequencies of the genotypes associated with fast and slow metabolism of medical products, and that, apparently, demands adaptation of medical products therapy schemes – substrata for each ethnos.

biotransformation, isoenzymes, polymorphism of genes, frequencies of distribution, ethnic groups

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